USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: CPNS1_HUMAN USC-OGP 2-DE database:  CPNS1_HUMAN CPNS1_HUMAN General information about the entry View entry in simple text format Entry name CPNS1_HUMAN Primary accession number P04632 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Calpain small subunit 1; Short=CSS1; AltName: Full=Calcium-activated neutral proteinase small subunit; Short=CANP small subunit; AltName: Full=Calcium-dependent protease small subunit; Short=CDPS; AltName: Full=Calcium-dependent protease small subunit 1; AltName: Full=Calpain regulatory subunit;. Gene name Name=CAPNS1 Synonyms=CAPN4, CAPNS Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0182: pI=4.94; Mw=26471 SPOT OGP-0248: pI=4.79; Mw=16912 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1274: pI=6.07; Mw=27522 SPOT OGP-1275: pI=5.05; Mw=27445 SPOT OGP-1286: pI=6.01; Mw=25688 Cross-references UniProtKB/Swiss-Prot P04632; CPNS1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CPNS1_HUMAN Primary accession number P04632 Secondary accession number(s) A8K0P1 Q8WTX3 Q96EW0 Sequence was last modified on  August 13, 1987 (version 1) Annotations were last modified on  March 15, 2017 (version 192) Name and origin of the protein Description RecName: Full=Calpain small subunit 1; Short=CSS1; AltName: Full=Calcium-activated neutral proteinase small subunit; Short=CANP small subunit; AltName: Full=Calcium-dependent protease small subunit; Short=CDPS; AltName: Full=Calcium-dependent protease small subunit 1; AltName: Full=Calpain regulatory subunit; Gene name Name=CAPNS1 Synonyms=CAPN4, CAPNS Encoded on Name=CAPNS1; Synonyms=CAPN4, CAPNS Keywords 3D-structure; Acetylation; Calcium; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X04106; CAA27726.1; -; mRNA EMBL M31511; AAA35646.1; -; Genomic_DNA EMBL M31502; AAA35646.1; JOINED; Genomic_DNA EMBL M31503; AAA35646.1; JOINED; Genomic_DNA EMBL M31504; AAA35646.1; JOINED; Genomic_DNA EMBL M31505; AAA35646.1; JOINED; Genomic_DNA EMBL M31506; AAA35646.1; JOINED; Genomic_DNA EMBL M31507; AAA35646.1; JOINED; Genomic_DNA EMBL M31508; AAA35646.1; JOINED; Genomic_DNA EMBL M31509; AAA35646.1; JOINED; Genomic_DNA EMBL M31510; AAA35646.1; JOINED; Genomic_DNA EMBL AK289606; BAF82295.1; -; mRNA EMBL BT009775; AAP88777.1; -; mRNA EMBL AY789642; AAV40829.1; -; Genomic_DNA EMBL AD001527; AAB51183.1; -; Genomic_DNA EMBL AC002984; AAB81546.1; -; Genomic_DNA EMBL BC000592; AAH00592.1; -; mRNA EMBL BC007779; AAH07779.1; -; mRNA EMBL BC011903; AAH11903.1; -; mRNA EMBL BC017308; AAH17308.1; -; mRNA EMBL BC018931; AAH18931.1; -; mRNA EMBL BC021933; AAH21933.1; -; mRNA EMBL BC023643; AAH23643.1; -; mRNA EMBL BC064998; AAH64998.1; -; mRNA CCDS CCDS12489.1; -; . PIR A26107; CIHUL; . RefSeq NP_001003962.1; NM_001003962.2; . RefSeq NP_001289561.1; NM_001302632.1; . RefSeq NP_001289562.1; NM_001302633.1; . RefSeq NP_001740.1; NM_001749.3; . RefSeq XP_005259352.1; XM_005259295.1; . RefSeq XP_005259353.1; XM_005259296.1; . UniGene Hs.515371; -; . PDB 1KFU; X-ray; 2.50 A; S=85-268 PDB 1KFX; X-ray; 3.15 A; S=85-268 PDB 4PHJ; X-ray; 1.60 A; A/B=96-268 PDB 4PHK; X-ray; 2.05 A; A/B=96-268 PDB 4PHM; X-ray; 2.03 A; A/B=96-268 PDB 4WQ2; X-ray; 1.64 A; A/B=96-268 PDB 4WQ3; X-ray; 1.79 A; A/B=96-268 PDB 5D69; X-ray; 1.97 A; A/B=96-268 PDBsum 1KFU; -; . PDBsum 1KFX; -; . PDBsum 4PHJ; -; . PDBsum 4PHK; -; . PDBsum 4PHM; -; . PDBsum 4WQ2; -; . PDBsum 4WQ3; -; . PDBsum 5D69; -; . ProteinModelPortal P04632; -; . SMR P04632; -; . BioGrid 107276; 59; . IntAct P04632; 25; . MINT MINT-5000880; -; . STRING 9606.ENSP00000246533; -; . BindingDB P04632; -; . ChEMBL CHEMBL2111357; -; . DrugBank DB02570; PD150606; . iPTMnet P04632; -; . PhosphoSitePlus P04632; -; . SwissPalm P04632; -; . BioMuta CAPNS1; -; . DMDM 115612; -; . OGP P04632; -; . REPRODUCTION-2DPAGE IPI00025084; -; . SWISS-2DPAGE P04632; -; . EPD P04632; -; . MaxQB P04632; -; . PaxDb P04632; -; . PeptideAtlas P04632; -; . PRIDE P04632; -; . TopDownProteomics P04632; -; . DNASU 826; -; . Ensembl ENST00000246533; ENSP00000246533; ENSG00000126247; . Ensembl ENST00000588815; ENSP00000464849; ENSG00000126247; . GeneID 826; -; . KEGG hsa:826; -; . UCSC uc002odi.2; human; . CTD 826; -; . DisGeNET 826; -; . GeneCards CAPNS1; -; . HGNC HGNC:1481; CAPNS1; . HPA HPA006872; -; . MIM 114170; gene; . neXtProt NX_P04632; -; . OpenTargets ENSG00000126247; -; . PharmGKB PA26067; -; . eggNOG KOG0037; Eukaryota; . eggNOG ENOG410YKQK; LUCA; . GeneTree ENSGT00620000087734; -; . HOGENOM HOG000063658; -; . HOVERGEN HBG004492; -; . InParanoid P04632; -; . KO K08583; -; . PhylomeDB P04632; -; . TreeFam TF314682; -; . BRENDA 3.4.22.53; 2681; . BRENDA 3.4.22.B24; 2681; . Reactome R-HSA-1474228; Degradation of the extracellular matrix; . Reactome R-HSA-6809371; Formation of the cornified envelope; . Reactome R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; . ChiTaRS CAPNS1; human; . EvolutionaryTrace P04632; -; . GeneWiki CAPNS1; -; . GenomeRNAi 826; -; . PRO PR:P04632; -; . Proteomes UP000005640; Chromosome 19; . Bgee ENSG00000126247; -; . CleanEx HS_CAPNS1; -; . ExpressionAtlas P04632; baseline and differential; . Genevisible P04632; HS; . GO GO:0005829; C:cytosol; IDA:BHF-UCL; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:BHF-UCL; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0005509; F:calcium ion binding; IEA:InterPro; . GO GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; TAS:ProtInc; . GO GO:0004175; F:endopeptidase activity; TAS:Reactome; . GO GO:0070268; P:cornification; TAS:Reactome; . GO GO:0022617; P:extracellular matrix disassembly; TAS:Reactome; . GO GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc; . GO GO:0016241; P:regulation of macroautophagy; NAS:ParkinsonsUK-UCL; . CDD cd00051; EFh; 1; . Gene3D 1.10.238.10; -; 1; . InterPro IPR011992; EF-hand-dom_pair; . InterPro IPR018247; EF_Hand_1_Ca_BS; . InterPro IPR002048; EF_hand_dom; . Pfam PF13202; EF-hand_5; 1; . Pfam PF13833; EF-hand_8; 1; . SUPFAM SSF47473; SSF47473; 1; . PROSITE PS00018; EF_HAND_1; 2; . PROSITE PS50222; EF_HAND_2; 3; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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